Itunes connection

I have an itunes activity set up and all works fine at first. After several hours roomie can’t control itunes anymore. Guide is blank and no music control. This happens if itunes is inactive or playing music that was initiated by roomie. The only way I am able to correct this is to restart itunes. Latest version of itunes is always running on a mac mini set to never sleep and hard disk never spins down, router airport extreme.