Two Xantech adapter blocks and one IP2IR

Can you use two ports on the IP2set unit to send commands to two different Xantech connecting blocks? I have two rooms each using their own Xantech block. All the equipment is located in the same media room. The only remote items are the TV’s.

Sure. Just make sure each of those ports has the GC-CGX cable to adapt it to the Xantech blocks.